Synthesis, molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors
ZP Xiao, ZY Peng, JJ Dong, RC Deng, XD Wang… - European journal of …, 2013 - Elsevier
Inhibition of urease results in Helicobacter pylori growth arrest in the stomach, promoting
urease as promising targets for gastrointestinal ulcer therapy. Twenty hybrid derivatives of
flavonoid scaffold and hydroxamic acid, β-hydroxy-β-phenylpropionylhydroxamic acids,
were therefore synthesized and evaluated against H. pylori urease. Biological evaluation of
these compounds showed improved urease inhibition exhibiting micromolar to mid-
nanomolar IC 50 values. Most importantly, 3-(3-chlorophenyl)-3-hydroxypropionyl …
urease as promising targets for gastrointestinal ulcer therapy. Twenty hybrid derivatives of
flavonoid scaffold and hydroxamic acid, β-hydroxy-β-phenylpropionylhydroxamic acids,
were therefore synthesized and evaluated against H. pylori urease. Biological evaluation of
these compounds showed improved urease inhibition exhibiting micromolar to mid-
nanomolar IC 50 values. Most importantly, 3-(3-chlorophenyl)-3-hydroxypropionyl …
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